".all other games meaningless at this point.."
The players should play like savages no matter what the overall meaning if the game becomes. First, they are still playing for an at-large bid. Second, if that's impossible then they play for a bye in Conference. Last, if that slips away then they play as a spoiler to stick it to other teams so they can also enjoy some pain.
But for a fan, the number of losses to look for are "5" and "8". 5 conference losses or less gives us a chance at an at large bid when you compare what our record would be to past "last in" teams. If we lose more than 5, then 8 conference losses becomes the immediate goal. Traditionally a 10-8 Conference record gets you a first day bye.