Based on his history and that of coach Cotton it will be a run first offense but out of some spread looks. Think the Auburn offense or even the Nebraska offenses the last couple years. I think you will see some under center stuff and some pistol formation/spread looks that emphasize the run. The passing game will be a lot simpler with faster quicker reads.
You'll see more sets with a loaded backfield, lead blockers, etc. Sanchez will throw the ball and spread the field also but he likes to control the ground attack.